WebOct 7, 2024 · TAX2 peptide is a cyclic peptide that acts as an orthosteric antagonist for thrombospondin-1 (TSP-1) interaction with CD47. TAX2 was first described for its anti … WebMembers of the thrombospondin (TSP) family of proteins have been implicated in wound healing. The cells of the corneal stroma (keratocytes) are capable of synthesising TSP-1 …
Author notes - American Society of Hematology
WebMay 1, 2007 · Indeed, experiments conducted on mice deficient for CD47 or its ligands, TSP1 and TSP2, show a similar defect in controlling the length of inflammation and in apoptosis of infiltrating T cells. We assume that the similarity observed in these null mouse phenotypes after the induction of DTH reactions can be attributed, at least in part, to a … WebEnter the email address you signed up with and we'll email you a reset link. mec wood handle
独家原创 CD47 相关信号通路及其与相关疾病关系的研究进展 - 癌 …
WebAug 23, 2007 · CD47 and thrombospondin 1 and 2 (TSP1 and TSP2) expression were analysed by real-time reverse transcription polymerase chain reaction in fluorescence … WebThrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 … WebMay 21, 2014 · 4N1K is a peptide fragment derived from the C-terminal, globular domain of thrombospondin which has been shown to mediate integrin-dependent cell adhesion and promote integrin activation acting via the cell-surface receptor, CD47. However, some studies found that 4N1K could act independently of CD47, putting in question the … pei wei carrollwood fl